• Cells and tissues analysis using Raman spectroscopy techniques (FT-micro-Raman, confocal Raman, portable Raman);
• Early diagnostic at molecular level in skin pathology: skin from mice models exposed to UVB and chemical cancer promoters is analysed using simple or functionalized noble metal nanoparticles suitable for surface enhanced Raman scattering (SERS);
• SERS tagging in molecular diagnostic and therapy monitoring;
• SERS sensing for early diagnostic;
• In vivo depth profiling of skin tissue;
   

Fig. 1 Typical Raman spectra collected from different organs of rat specimen

Fig.3 Histopathology correlation: binuclear hepathocytes.

Fig. 2  Typical SERS spectra collected from damaged skin tissue

Fig.4 Tumoral tissue screening

• Therapy monitoring using Raman spectroscopy techniques:
  obtaining and characterization of new pharmaceuticals based on Betula Pendula Roth natural extracts with antitumor activity;
• New strategies in obtaining, pharmaceutical formulation, characterization and toxicological evaluation of new betulin-based drugs from natural sources